The therapy of secondary hyperparathyroidism (SHPTH) in patients with advanced chronic kidney disease (CKD) presenting with 25-hydroxyvitamin D deficiency is not well established. Three approaches are ...
Therapy of Hyperparathyroidism in CKD
Nephrology Viewpoints by Richard Glassock
Prognostic Significance of Persistent Hematuria in IgA Nephropathy
Persistent high-grade hematuria is associated with an adverse impact on prognosis in IgA Nephropathy (IgAN), independent of proteinuria according to retrospective observational studies...
eGFR Calculations and Obesity
The definition of chronic kidney disease (CKD) using estimated glomerular filtration (eGFR) equations (indexed to a standard body surface area [BSA] of 1.73 m2) has been recognized as...
Calcium Deposition in Kidney Biopsy Specimens
Calcium deposition in the kidney parenchyma (using special stains such as the von Kossa stain), also known as dystrophic calcification, is a relatively common finding (about 10%) in native kidney biopsy specimens...
Serum Uromodulin Levels in IgA Nephropathy (IgAN): A Biomarker of Injury?
Uromodulin (UMOD or Tamm-Horsfall Protein) is synthesized and secreted by the thick ascending limb of the loop of Henle in the kidney. Mutations of the UMOD gene have been linked to...
Predictions of Outcomes in IgA Nephropathy
Accurate and reproducible prediction of the long-term (5–10 years) outcomes in individuals or groups of patients with biopsy-proven IgA nephropathy (IgAN) is a very desirable goal.....
Fibrillary Glomerulonephritis and Protein Folding
Fibrillary glomerulonephritis (FGN) is a rare form of primary glomerular disease defined by the common co-deposition of IgG and DNAJB9 and fibril formation. Its etiology and pathogenesis are unknown...
Interstitial Inflammation as a Prognostic Factor in IgA Nephropathy
Prediction of the long-term outcomes in individual patients with IgA nephropathy (IgAN) using pathological parameters has long been a “holy grail” in Nephrology....
COVID Vaccination and Kidney Disease
The COVID-19 pandemic unleashed a new wave (indeed a torrent) of an old and well-recognized phenomenon; namely, the development of de novo or an exacerbation of underlying kidney disease in...
Outcomes in Anti-GBM Disease
Anti-GBM disease poses a serious threat to survival and preservation of kidney function, especially if it is discovered or treated late in its evolution. It is a rare disease...